Autophagy is an intracellular process that is involved in a bulk degradation of organelles, misfolded or long-lived proteins and bacterial pathogens. This process is widely conserved from yeast to eukaryotes. Glitches in the human autophagy pathway can lead to cancer, neurodegenerative disorders such as Alzheimer’s and Parkinson’s, gastrointestinal disorders, liver disease and heart disease. Autophagy is regulated by the ATG1/ULK1 complex (comprising ATG13, ULK1, ATG101 and FIP200). Although it is known that FIP200 interacts with ATG13 directly, the ATG13 binding region within FIP200 is unknown.  We aim to identify the interacting region of ATG13 in FIP200, and solve the structure of the ATG13 and FIP200 complex by the macromolecular crystallography.