<em>De novo</em> Designed Peptides Inhibit Amyloid Formation in Multiple Systems — ASN Events
  1. Schedule
  2. Session Twelve - Poster Session D including Happy Hour & Trade Display
  3. De novo Designed Peptides Inhibit Amyloid Formation in Multiple Systems

De novo Designed Peptides Inhibit Amyloid Formation in Multiple Systems (#413)

Gene Hopping 1 , Jackson Kellock 1 , Byron Caughey 2 , Valerie Daggett 1
  1. Department of Bioengineering, University of Washington, Seattle, WA, USA
  2. Laboratory of Persistant Viral Diseases, NIAID/NIH Rocky Mountain Laboratories, Hamilton, MT, USA
Publish consent withheld
  1. Daggett, V. α-Sheet: The Toxic Conformer in Amyloid Diseases? Acc. Chem. Res. 39, 594–602 (2006).
  2. Armen, R. S., DeMarco, M. L., Alonso, D. O. & Daggett, V. Pauling and Corey's α-pleated sheet structure may define the prefibrillar amyloidogenic intermediate in amyloid disease. Proc. Natl. Acad. Sci. USA 101, 11622–11627 (2004).
  3. Armen, R. S., Alonso, D. O. V. & Daggett, V. Anatomy of an Amyloidogenic Intermediate: Conversion of β-Sheet to α-Sheet Structure in Transthyretin at Acidic pH. Structure 12, 1847–1863 (2004).
  4. Pauling, L. & Corey, R. B. The pleated sheet, a new layer configuration of polypeptide chains. Proc. Natl. Acad. Sci. U.S.A. 37, 251–256 (1951).