A fast and robust NMR-based method to generate structural data for protein-fragment complexes that are not amenable to X-ray crystallography  — ASN Events

A fast and robust NMR-based method to generate structural data for protein-fragment complexes that are not amenable to X-ray crystallography  (#416)

Biswaranjan Mohanty 1 , Martin Williams 1 , Bradley Doak 1 , Jamie Simpson 1 , Mehdi Mobli 2 , Martin Scanlon 1
  1. Monash Institute of Pharmaceutical Sciences, Parkville, VIC, Australia
  2. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
Publish consent withheld
  1. Hajduk, J. P., Nat Chem Biol. 2006, 2, 658-659.
  2. Macarron, R.; Banks, N. M.; Bojanic, D.; Burns, J. D.; Cirovic, A. D.; Garyantes, T.; Green, V. S. D.; Hertzberg, R. P.; Janzen P. W.; Paslay, W. J.; Schopfer, U. and Sittampalam, S. G.,Nat Rev Drug Discovery 2011, 10, 188-195.
  3. Shah, M. D.; AB, E.; Diercks, T.; Hass, A. S. M.; van Nuland, A. J. N. and Siegal, G., J. Med. Chem. 2012.
  4. Otten, R.; Chu, B.; Krewulak, K.D.; Vogel, H.J. and Mulder, F.A.A., J. Am. Chem. Soc. 2010, 132, 2952-2960.
  5. Horne, J.; d’Auvergne, E. J.; Coles, M.; Velkov, T.; Chin, Y.; Charman, W.N; Prankerd, R.; Gooley, P.R. and Scanlon, M.J., J. Mol. Biol. 2007, 371, 703-716.