AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which senses changes in energy availability in the form of changing adenosine nucleotide ratios² . As a promoter of lipid oxidation and plasma glucose lowering pathways, its activation is desirable for the treatment of metabolic disorders, most notably Type 2 diabetes¹ . Exercise and caloric restriction have been identified as effective physiological methods for activating AMPK, however direct pharmacological activators remain largely uncharacterised. Understanding drug-binding sites, isoform specificity and mechanism of action of known AMPK activators is crucial in the development of more effective treatments of metabolic disorders.