Session Five - Poster Session A — ASN Events

Session Five - Poster Session A — ASN Events

Session Five - Poster Session A

Characterisation of Novel Small Compound Activators of AMPK (#101)

Regulation of Bax and Bak at the mitochondrial outer membrane (#102)

Thanh Nguyen Ngoc

Ndufaf2 assists mitochondrial complex I biogenesis by stablizing the productive assembly of a late-stage intermediate (#103)

GloA2; the entire methylglyoxal detoxification pathway in one enzyme (#104)

Rohan Bythell-Douglas

Dipeptidyl Peptidase 9 in Apoptosis (#105)

The first structural characterisation of diaminopimelate decarboxylase from a plant (#106)

Jennifer Crowther

Design and characterisation of bacterial haloalkane dehalogenases (#107)

Targeted inactivation of Dipeptidyl Peptidase 9 enzyme activity in mice (#108)

Margaret G Gall

Probing the role of ASD duplication in Bacillus anthracis (#109)

Mohamed Ilyas Kamal

Characterization of fragment inhibitors of HIV-1 RT using functional assays (#110)

Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-inactivates (#111)

Chris G Langendorf

A novel role for Glutathione transferase Omega 1 in the glutathionylation cycle (#112)

Targeting the non-conserved residue Q859 in the rational design of PI3Kα selective inhibitors (#113)

Michelle S Miller

Back to the Future: Can ancient enzymes help design a new antibiotic? (#114)

Matilda S Newton

Unravelling the Role of the Quaternary Structure of Diaminopimelate Decarboxylase from Diverse Bacterial Species (#115)

Martin G Peverelli

Small Angle X-ray Scattering (SAXS) studies of human plasminogen (#116)

Evolutionary mechanism of enzyme adaptation to take advantage of a changed nucleophile (#117)

Molecular Evolution in Quaternary Structure and Allosteric Regulation of Dihydrodipicolinate Synthase from the Cyanobacterium Prochlorococcus marinus (#118)

Finding the Achilles' Heel in the Superbug Golden Staph: Targeting Biotin Protein Ligase (#119)

Tatiana P. Soares da Costa

The Structural and Functional Characterisation of Thioesterases within Yersina pseudotuberculosis, Mycobacterium paratuberculosis, and Legionella pneumophila (#120)

Crystall M D Swarbrick

Synthesis and Biological Evaluation of N²,N⁴-dibenzylquinazoline-2,4-diamine Analogues as Anti-Malarial Agents (#121)

A fragment-based approach to inhibitors of DsbA: combatting virulence in Gram-negative bacteria (#122)

Mansha Vazirani

Subcellular localisation in the Prolyl OligoPeptidases (#123)

The Metamorphic CLIC1 Protein Requires Cholesterol for Optimal Conduction In Membranes (#124)

Mapping the Chloride Permeation Pathway of a Human Glutamate Transporter (#125)

Rosemary J Cater

Impact of pathogenic bacterial protein (PorB) , on host cell mitochondria (#126)

Quantitative Analysis of Plasma Membrane Proteins Following Cell Stress (#127)

Dissecting mitochondrial complex I biogenesis using TALEN technology (#128)

The evolution of mitochondrial protein import pathways revealed by the fungal pathogen Candida albicans (#129)

Victoria Hewitt

Structural studies of the proton-translocating subunit of the A-type ATP synthase. (#130)

Sided inhibition of glutamate transporter homologue reconstituted into liposomes reveals oriented kinetics of transport cycle. (#131)

Benjamin C McIlwain

Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis (#132)

Sam L Palframan

Insights into the pore structure of the MACPF/CDC superfamily (#133)

The role of mitochondria in cell death – regulation of the pro-apoptotic protein Bak (#134)

Cell-free protein expression of neuropeptide GPCRs (#135)

Patrick J Shilling

The TAM complex is required for assembly of some type V secretion systems, including autotransporters (#136)

Christopher J Stubenrauch

Functional expression in Escherichia coli and stabilisation of the relaxin-3 receptor, RXFP3 (#137)

A conformational study of an aragonite-stabilizing peptide using molecular simulation. (#138)

The Potassium Channel Blocker ShK Toxin: Dynamics and Conformational Heterogeneity in Solution (#139)

Towards Coarse-Grained Modelling of Peptide-Mediated Nanoparticle Assembly in 3D (#140)

Conopeptide Analogues that Target Sodium Channels with Improved Activity Towards NaV1.3 (#141)

Peptides for Pain: Dicarba α-Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABA_B Receptors (#142)

Samuel D. Robinson

Efficient conformational sampling at peptide-mineral interfaces: Insights from a quartz-binding peptide. (#143)

Louise B. Wright

Production of complexes of the pro-apoptotic protein Bak for structural studies (#144)

Investigation of interactions occurring at the extracellular loops of RXFP1 (#145)

Natalie A Diepenhorst

Template production pipeline for high throughput in vitro protein expression and analysis (#146)

New tools for identifying nature's solutions for improving CO₂ fixation (#147)

Enrichment for Low Abundant Proteins and Peptides from Ruminant Milk (#148)

Structure, Function and Inhibition of Aspartate Semialdehyde Dehydrogenase from Methicillin-resistant Staphylococcus aureus (MRSA) (#149)

Characterisation of tethered Ldb1–LIM-only complexes (#150)

Krystal L Lester

New Capabilities in Examining Rubisco Subunit Interactions in Higher Plant Plastids (#151)

Creating nano-lego: engineered protein rings as bio-building blocks (#152)

Francesca Manea

Recombinant plant-made puroindolines exhibit anti-microbial activity and interactions in a plant system (#153)

Azadeh Niknejad

Analysis of proteins contributing to sea urchin roe colour; including the expression and characterisation of a carotenoid-binding protein from Evechinus chloroticus. (#154)

A structural, biophysical and computational investigation of two sequence-based protein engineering methods (#155)

Benjamin T Porebski

Directed evolution of an α/β hydrolase fold enzyme for improved catalytic activity toward non-physiological p-nitrophenyl ester substrates (#156)

Comparison of different immobilized-metal affinity chromatography (IMAC) resins for their ability to purify recombinant His-tagged proteins expressed in Escherichia coli and insect cells. (#157)

Protein amyloids exhibit intrinsic fluorescence (#158)

Structural Studies of Alzheimer’s Disease Amyloid Precursor Protein – Towards Understanding Its Mechanism of Dimerisation (#159)

Structural Capacitance in Protein Evolution and Human Diseases (#160)

Mutational analysis of apolipoprotein C-II amyloid fibril assembly pathways (#161)

Molecular dissection of the ClpP protease from Mycobacterium smegmatis: assembly and activation. (#162)

Improved resolution of macrophage migration inhibitory factor complexed with phenethyl isothiocyanate (#163)

Aimée L. Gommans

Association of detailed Drug data with predicted candidate genes in Gentrepid (#164)

Fragment-Based Inhibitor Design against a Plasmodium falciparum Surface Antigen (#165)

Structural and chemical studies targeting pro-survival Bcl-2 family members (#166)

Structural insights into the GABA_A receptor as a target against tumour progression. (#167)

Catherine S Vacher

Structure-based Drug Design of SPSB2-iNOS Inhibitors: Identification of Potential Lead Compounds via In Silico Screening, NMR and SPR Experiments (#168)