A Structural Study in Developing New Antidiabetic PPARγ Modulators (#201)

9:00 PM

John B Bruning

A Truncated Fragment of Src Protein Kinase Generated by Calpain-Mediated Cleavage is A Mediator of Neuronal Death in Excitotoxicity (#202)

9:00 PM

Heung-Chin Cheng

Structural and Functional Analysis of the GM-CSF:GM-CSF Receptor Alpha Chain Binary Complex (#203)

9:00 PM

Mara Dottore

Apical ring protein RNG2 is critical for host cell invasion in Toxoplasma gondii. (#204)

9:00 PM

Nicholas J Katris

β-subunit determinants conferring isoform specificity to direct AMPK activators (#205)

9:00 PM

Jon S Oakhill

Investigating the Mechanism of Allosteric Control in a Crucial Biosynthetic Enzyme (#207)

9:00 PM

Penelope (Penel) J Cross

Crystal structures reveal a second binding mode of thiophene inhibitors of PDE4 (#208)

9:00 PM

Susanne C. Feil

Fibroblast Activation Protein in chronic disease (#209)

9:00 PM

Mark D Gorrell

The quantitation and in vivo distribution of Fibroblast Activation Protein (FAP) enzymatic activity. (#210)

9:00 PM

Fiona M Keane

Exploring the quaternary structure of Pyrococcus furiosus DAH7PS (#211)

9:00 PM

Ali Reza Nazmi

Template guided synthesis of inhibitors of biotin protein ligase. (#212)

9:00 PM

Steven W Polyak

Critical non-conserved residues that dictate PI3 kinase inhibitor selectivity identified by site-directed mutagenesis (#213)

9:00 PM

Zhaohua Zheng

Expression, purification and crystallization of a membrane protein from Neisseria meningitides - LptA (#214)

9:00 PM

Anandhi Anandan

The C-terminal b-signal-like motif of TamB facilitates efficient autotransporter secretion (#215)

9:00 PM

Matthew J Belousoff

  Intracellular β-Nicotinamide Adenine Dinucleotide Inhibits the Skeletal Muscle ClC-1 Chloride Channel (#216)

9:00 PM

Brett Bennetts

Evolution and functional diversity of the Omp85 superfamily (#217)

9:00 PM

Eva Heinz

alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms (#218)

9:00 PM

Andreas Hofmann

Towards the production of an HIV-1 subunit vaccine: structural and immunological characterisation of novel plant-based HIV-1 Gag/dgp41 virus-like particles (#219)

9:00 PM

Sarah A. Kessans

TSPAN12 stabilises β-catenin and fundamentally regulates tumor growth and metastasis  (#220)

9:00 PM

Konstantin Knoblich

Aromatic rescue of glycines in autotransporter β-barrels (#221)

9:00 PM

Denisse L Leyton

Cloning, Expression, Purification and Crystallisation of Bacterial Drug Targets for Structural Determination (#222)

9:00 PM

Jason J Paxman

Insertion and assembly of mitochondrial outer membrane proteins (#223)

9:00 PM

Miguel Shingu-Vazquez

Structural basis of chemokine recognition by sulfotyrosine residues in chemokine receptors (#224)

9:00 PM

Martin J Stone

Toxin disulfide bond mimetics (#225)

9:00 PM

Paul Alewood

Discovery of a novel Kv1.3 ion channel blocker and a natural immunosuppressant peptide in a hookworm (#226)

9:00 PM

Sandeep Chhabra

Interaction of the non-phosphorylated cyclic peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity (#227)

9:00 PM

Menachem J Gunzburg

Quantifying Protein-Protein Binding via Composition-Gradient Static Light Scattering (CG-MALS) (#228)

9:00 PM

Chris Broomell

Crystal structures of Bax Reveal the Molecular Events that Initiate Programmed Cell Death (#229)

9:00 PM

Peter E Czabotar

Characterisation of the autoinactivation mechanism of GAD65 and its role in autoimmunity and neurotransmitter homeostasis (#230)

9:00 PM

Itamar Kass

Using SAXS to understand specificity: HIV-1 envelope glycoprotein interactions with a dendrimer microbicide that blocks HIV entry to host cells (#231)

9:00 PM

Catherine F Latham

Conformational control of P450aromatase (CYP19) by lipid membrane interactions and protein associations (#232)

9:00 PM

Lisandra L Martin

Proof-reading exonuclease on a tether: the subunit ɛ of E. coli DNA polymerase III is tied to the polymerase subunit ɑ at a site far from the active site of DNA replication (#233)

9:00 PM

Kiyoshi Ozawa

Mapping of Protein-Protein Interactions in the Mediator Complex with Microfluidics and Alpha Screen (#234)

9:00 PM

Mark Polinkovsky

NMR solution structures of DsbA oxidoreductases as a component of Fragment Based Drug Design (#235)

9:00 PM

Kieran Rimmer

Exposing the flexibility of human parainfluenza virus haemagglutinin-neuraminidase (#236)

9:00 PM

Moritz Winger

Domain seeking: A method for identifying soluble fragments of difficult protein targets. (#237)

9:00 PM

Esther MM Bulloch

Engineering enzymes to turn gas-eating bacteria into chemical factories (#238)

9:00 PM

Monica L Gerth

Biochemical reconstitution of a large ubiquitin ligase complex using the MultiBac expression system. (#239)

9:00 PM

Vince J Murphy

The importance of the 5’rbcL coding sequence for co-translational processing and biogenesis of tobacco Rubisco. (#240)

9:00 PM

Douglas Orr

Tuning gas binding in heme proteins (#241)

9:00 PM

Trevor D Rapson

SDAR: a practical tool for graphical analysis of two-dimensional data (#242)

9:00 PM

Patricia Walden

Tetracysteine exposure to track open and closed Src family kinase conformations in the cell  (#243)

9:00 PM

Rebecca Wood