TSPAN12 stabilises β-catenin and fundamentally regulates tumor growth and metastasis  — ASN Events
  1. Schedule
  2. Session Seven - Poster Session B includes Happy Hour & Trade Display
  3. TSPAN12 stabilises β-catenin and fundamentally regulates tumor growth and metastasis 

TSPAN12 stabilises β-catenin and fundamentally regulates tumor growth and metastasis  (#220)

Konstantin Knoblich 1 2 3 , Anne L. Fletcher 1 4 , Chandan Sharma 1 2 , Hong-Xin Wang 1 2 , Qinglin Li 1 2 , Fenghui Xu 1 2 , Shannon J. Turley 1 4 , Martin E. Hemler 1 2
  1. Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA, USA
  2. Harvard Medical School, Boston, MA, USA
  3. Structural Biology Division Walter and Eliza Hall Institute of Medical Research 1G Royal Parade Parkville, VIC Australia, Parkville, VIC, Australia
  4. Microbiology & Immunology, Harvard Medical School, Boston, MA, USA
Regulation of β-catenin is strongly associated with tumor growth and metastasis. In-depth analysis of TSPAN12 in primary and metastatic tumors demonstrated that TSPAN12 is important for preserving primary tumor growth and inhibiting metastasis in in vivo mouse models. Additionally, we show that TSPAN12 plays a major role in suppressing apoptosis induction in primary tumors, as well as increasing β-catenin stability via LRP5/FZD4 association, leading to decreased metastatic potential. Finally, we uncovered a variety of genes from primary tumors associated with TSPAN12 ablation that are pivotal downstream targets of β-catenin. These results provide the first evidence for a fundamental role of TSPAN12 in cancer progression and metastasis.